These tweets are selected automatically with #rstats code. Please inform me if any is inappropriate. See other #IHCPath pages here: https://serdarbalci.netlify.com/categories/IHCPath/ or here: https://serdarbalci.wordpress.com/?s=IHCPath/ See selected social media based textbook project here: http://www.patolojinotlari.com/
#pulmpath MonPMPoster#267 Inter-Observer Reproducibility PD-L1 IHC Interpretation Improves with Training @JL_Sauter https://t.co/wX06NYo2Da
— Samson W. Fine, MD (@rovingatuscap) March 6, 2017
#pulmpath MonPMPoster#253 M.Velez etal: Path Patterns Inflam Lung Injury postAnti-PD-1 #immunotherapy in Asympt pts https://t.co/B5iUy4f4IM
— Samson W. Fine, MD (@rovingatuscap) March 6, 2017
Mesothelioma v. lung adenoCA: no IHC + in 100% of one & neg in the other; TTF-1 is differential but only + in 80% of lung adeno #USCAP2015
— Samson W. Fine, MD (@rovingatuscap) March 22, 2015
#arthurpurdystout Soc - Dr. Colby: major challenge: mesothelioma v. lung adenoCA - considerable overlap in IHC -
— Samson W. Fine, MD (@rovingatuscap) March 22, 2015
26/
— Sanjay Mukhopadhyay (@smlungpathguy) March 8, 2020
The T cells that try to kill PD-L1 positive tumor cells eventually fail and become functionally inactive. They remain in the vicinity of the tumor, however, waiting to be unleashed some day. They express PD-1, CTLA-4 and TIM-3. What are these T cells called?
23/
— Sanjay Mukhopadhyay (@smlungpathguy) March 8, 2020
The answer is Osimertinib, at least at the current time. There is some evidence that immunotherapy may harm patients with driver mutations.
Also, Osimertinib is superior to other EGFR inhibitors in this setting (see FLAURA trial, below)https://t.co/ADzcKU18dC
17/
— Sanjay Mukhopadhyay (@smlungpathguy) March 7, 2020
The correct answer is lupus-like arthritis. These mice also developed glomerulonephritis. Since PD-1 deficient nice were developing autoimmune diseases, this meant PD-1 was somehow keeping the immune system in check. https://t.co/K2pWrOh9s8
12/
— Sanjay Mukhopadhyay (@smlungpathguy) March 7, 2020
Q6. When interpreting 22C3 PD-L1 immunohistochemistry for non-small cell lung carcinoma, which of these is true when calculating the TPS?
6/
— Sanjay Mukhopadhyay (@smlungpathguy) March 7, 2020
Q3. James Allison won the 2018 Nobel Prize for the discovery of CTLA-4. Who won the Nobel along with him for the discovery of PD-1?
4/
— Sanjay Mukhopadhyay (@smlungpathguy) March 7, 2020
Q2. Anti PD-1 immunotherapy affects primarily which type of immune cells?
Test your knowledge by answering the quiz and then scroll to the next tweet for the correct answer!
2/
— Sanjay Mukhopadhyay (@smlungpathguy) March 7, 2020
First question. When PD-1 on T cells binds PD-L1 on tumor cells, what happens to the T cells?
Thank you! Very interesting for me to learn that there is some element of judgement and discretion involved in this decision. As opposed to simply following a straightforward algorithm. #pathology #pulmpath #io #Immunotherapy #pdl1 #chemoio #ici
— Sanjay Mukhopadhyay (@smlungpathguy) March 7, 2020
Bronchial pneumonia. Lung, autopsy. HE and gram stain. pic.twitter.com/mtc3EDUCvU
— Pathology Walker@Auto Tweet Bot (@Patholwalker) July 27, 2019
Clear cell meningioma, WHO grade II. Cerebrum, resection. HE and EMA. pic.twitter.com/QlUT59BF53
— Pathology Walker@Auto Tweet Bot (@Patholwalker) July 23, 2019
Pulmonary tuberculosis. Ziehl-Neelsen stain and direct immunofluorescence (DIF). pic.twitter.com/aXghKuyhY5
— Pathology Walker@Auto Tweet Bot (@Patholwalker) October 18, 2018
Rathke's cleft cyst. Sellar lesion, excision. HE, CKAE1/AE3 and MRI(T2WI). pic.twitter.com/kIeWZagwLe
— Pathology Walker@Auto Tweet Bot (@Patholwalker) March 27, 2018
Olfactory neuroblastoma. HE, synaptophysin and S-100P, respectively. pic.twitter.com/lwbxrXMs29
— Pathology Walker@Auto Tweet Bot (@Patholwalker) November 2, 2017
Intestinal spirochetosis, colon biopsy. HE and T. pallidum (cross reaction). pic.twitter.com/v0KNBA9tGY
— Pathology Walker@Auto Tweet Bot (@Patholwalker) November 2, 2017
Epithelioid hemangioendothelioma, Liver core needle biopsy. HE stain, CD31 and Factor VIII, respectively. pic.twitter.com/p0cKIVPi3K
— Pathology Walker@Auto Tweet Bot (@Patholwalker) November 1, 2017
Herpes simplex infection. Pap stain. pic.twitter.com/NfAjaaIHeq
— Pathology Walker@Auto Tweet Bot (@Patholwalker) October 31, 2017
In nasopharynx, the name is still NPC, nonkeratinizing, undifferentiated type. Outside of nasopharynx, it is lymphoepithelial carcinoma or lymphoepithioma-like carcinoma.
— Bin Xu (@BinXu16) July 4, 2019
A small % of NPC is HPV-related, esp in Caucasian population.
+1, EBV NPC first. Although NPC in general was considered as squamous cell ca, I do see p40/CK56 negative NPC. Is the patient Asian? Not uncommon for NPC and oropharyngeal scc to present with neck lymph node with occult primary.
— Bin Xu (@BinXu16) July 4, 2019
But why did @ariella8 tag #pulmpath
Interesting. This looks more adenoca esp salivary duct carcinoma. Are they s100 neg AR pos? I do see ca ex pa with both myoepithelial ca & sdc or adenocarcinoma nos component...in any case on bx just high grade salivary gland ca with a diff will do..no need to push all the way.
— Bin Xu (@BinXu16) July 3, 2019
Breast: Tumor in a 45-Year-Old Woman
— Patrick J. McIntire (@PatMcIntireMD) May 11, 2020
Diagnosis? Supportive Immunostain?
1) Granular Cell Tumor
2) S100p Immunoreactivity is Supportive (nuclear and cytoplasmic staining) pic.twitter.com/cYbqv3dvAW
Speaker Nancy Pelosi Endorses Joe Biden For President | Joe Biden For Pr... https://t.co/gH2NfEA7ie via @YouTube
— Bennet Omalu (@bennetomalu9168) April 27, 2020
What do they stain with in terms of #ihcpath ?
— Sanjay Mukhopadhyay (@smlungpathguy) November 7, 2019
Poster session going on now #USCAP2020, shown here from left to right Drs. Andrea Khan, Isam Eltoum-Eldin, Shuko Harada, Meng-Jun Xiong and Cristina Magi-Galluzzi with a poster on cirrhotomimetic hepatocellular carcinoma #liverpath pic.twitter.com/UIiH3OmXpF
— UAB Pathology (@UABPathology) March 3, 2020
2/2 In this other case the lesions are more incipient and there is only C3 in the perilesional skin.
— Pascual Meseguer (@Histopatolomon) February 26, 2020
The eosinophils are positioning where there is going to be a vesicle.#pathology #dermatology #dermpath #bullous #BullousPemphigoid #immunofluorescence pic.twitter.com/5iM0FbuUUq
If we create a newer version of our shiny app can we call it a shinier app?
— Matthew Fox (@ProfMattFox) February 24, 2020
Esse Oscar nada acontece.... Feijoada
— Raul Franca (@RaulFranca1) February 10, 2020
What's a typical day like for a #BiomedicalScientist in cellular pathology? Have a read of #IBMS member Sarah Oliver's career profile online, where she talks stains, wax and tissue samples. #IBMSChat https://t.co/dYMHOO3MGF pic.twitter.com/zpeKVACen1
— IBMS #AtTheHeartOfHealthcare (@IBMScience) February 5, 2020
React Native Starter Apphttps://t.co/EXlyn5LpKv
— Java Script Briefly (@JavaScript_b) January 31, 2020
+1 JSBot #javascript
Little too big for ragged red fibers, but good guess!
— Craig Horbinski (@CraigHorbinski) January 4, 2020
What all-Red & all-Blue states are up to.
— Evren Celik Wiltse (@EvrenWiltse) December 30, 2019
A quick summary. https://t.co/Ahnz62MyOl
These tweets are selected automatically with #rstats code. Please inform me if any is inappropriate. See other #IHCPath pages here: https://serdarbalci.netlify.com/categories/IHCPath/ or here: https://serdarbalci.wordpress.com/?s=IHCPath/ See selected social media based textbook project here: http://www.patolojinotlari.com/
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